Maladie de buerger. I - Qu'est ce que c'est? A -Comment et par qui elle a était découverte? B- Comment elle se déclare? II-Comment voir. La maladie de Buerger est une thromboangéite oblitérante, atteignant les artères et les veines de petits et moyens calibre, surtout des membres. Parmi les rares. La maladie de Buerger ou thromboangéite oblitérante (TAO) associe une atteinte oblitérante des artères de moyen et petit calibres des quatre membres à des.


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Improvement was seen of active vascular lesions and pain symptoms.

Sang Thrombose Vaisseaux

The diagnosis and treatment of this entity is challenging, since it requires the exclusion of many other causes and a multidisciplinary approach.

An illustrative case-report and literature review is presented. Case presentation A year-old black male presented in the medicine clinics with a 6 year history of ulcers in the fingertips of both hands and feet with progressive worsening: A genetic predisposition has been proposed based on the higher incidence of this disease in Ashkenazi than in non-Ashkenazi Jews in Israel [ 7 ].

Either no association maladie de buerger an HLA antigen is observed [ 8 ], or conflicting results are obtained, with maladie de buerger series published to date being small and results being related to country of origin [ 9—12 ]. This increase may be due to an increase in smoking among women.


The maladie de buerger age of the patients is another key characteristic of TAO among the vasculitides [ 15—17 ]. The symptoms almost always begin before the age of 40 yrs. The link with smoking is one of the most original features of TAO. Almost all the patients affected are smokers, most of them heavy smokers [ 818 ].

Once the disease has become established, stopping smoking is the maladie de buerger way to prevent progressive flare-ups. Taking up smoking again, even years later, may trigger a new flare-up of the disease [ 814 ].

Maladie de buerger by thomas lacoste on Prezi

This maladie de buerger association suggests that tobacco plays a role in the pathogenesis of the disease or, at least, that tobacco is a highly contributive factor. It has been suggested that something, yet undefined, in nicotine may be involved.


All types of tobacco and cigarette paper have been implicated and a few cases have been described among users of smokeless tobacco [ 19 ]. These cases might be triggered by cold, frostbite, traumatism of the extremities or even abuse of sympathomimetic drugs [ 37maladie de buerger ].

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  • Background

Cases of juvenile arteritis with atherosclerotic lesions have been related to the use of Cannabis saliva or C. The role of cannabis was recently reconsidered, resulting in the description of a specific maladie de buerger arteritis [ 24 ].

Sang Thrombose Vaisseaux

Clinically cannabis arteritis is very similar to Buerger's disease and the reported differences in pathological lesions are not very convincing [ 25 ]. While nearly all patients with TAO use tobacco in some forms, the role of maladie de buerger remains more controversial and these habits should be considered as factors strongly contributory to TAO.

An impaired endothelium-dependent vasorelaxation in the peripheral vasculature, even in the non-diseased limbs, has been shown in patients with TAO [ 26 ]. Mild perturbations in clotting have been described but there is no evidence to maladie de buerger that hypercoagulability or fibrinolytic abnormalities play a major role [ 27 ].

Various investigations have also been carried out with the aim of identifying an autoimmune mechanism responsible for TAO [ 228—32 ].

Hypersensitivity to type I [ 228 ] and III [ 2 maladie de buerger collagen associated with the presence of anti-collagen [ 2 ] or anti-elastin [ 3032 ] antibodies has been shown.